Protein Flow Explorer — Interactive 3D Biology Visualizer

Protein Library

Select a structure to explore

⤓ Or drop .pdb / .cif file here

Structures from the RCSB PDB, AlphaFold and UniProt. Custom molecules stay in this session only.

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Sequence —

Representation

Style Color Opacity Background

Highlights

Description

Select a protein from the left panel to begin.

Measurement

Click atoms to measure distances, angles and dihedrals.

Tap "Pick atoms" then click in the viewer. Two picks → distance, three → angle, four → dihedral.

Structure Comparison

Load a second structure to superimpose and compute per-residue RMSD.

pLDDT Confidence (AlphaFold)

For AlphaFold structures, the B-factor column holds the per-residue pLDDT confidence score (0–100). High pLDDT = reliable prediction; low pLDDT = disordered / uncertain.

0 · very low70 · confident100 · very high

Conservation (MSA)

Fetches the protein and ~10 close homologs from UniProt, runs pairwise alignment in the browser, and colours each residue by its conservation across the family. variable conserved highly conserved

No conservation loaded.

Cancer Variants (ClinVar / COSMIC)

For human proteins, fetches known disease-associated variants from NCBI ClinVar and renders them as small spheres on the structure. Colour reflects clinical significance.

No variants loaded.

Pathogenic Likely path. VUS Likely ben. Benign

Pockets & Ligand Contacts

Detects solvent-excluded surface cavities (alpha-sphere grid scan) and, for any bound ligand, enumerates the residues within 4 Å of it — the standard drug-discovery contact analysis.

No pockets detected.

No ligand contacts.

Select a protein to see its guided tour.

Not every protein has a conformational-change trajectory. Try Hemoglobin, Adenylate Kinase, Calmodulin, or HIV-1 Protease.

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